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The following Unwanted side effects are widespread (developing in bigger than thirty%) for patients using azacitidine:
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VIDAZA is actually a pyrimidine nucleoside analog of cytidine. VIDAZA is thought to exert its antineoplastic consequences by causing hypomethylation of DNA and direct cytotoxicity on irregular hematopoietic cells in the bone marrow. The concentration of azacitidine required for optimum inhibition of DNA methylation in vitro would not lead to key suppression of DNA synthesis.
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From the Intent-to-Deal with Evaluation, sufferers dealt with with azacitidine shown a statistically sizeable change in Total survival in comparison with people treated Get More Info with CCR (median survival of 24.
A single situation of overdose with VIDAZA was reported in the course of clinical trials. A individual experienced diarrhea, nausea, and vomiting just after acquiring an individual IV dose of roughly 290 mg/m², Nearly 4 occasions the proposed starting up dose.
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Maintenance Dose: The dose may very well be greater to one hundred mg/m2 if no effective influence is found immediately after two treatment method cycles and if no toxicity apart from nausea and vomiting has occurred.